Ian J. Deary

General cognitive function and the brain's structural connectome

The paper shows that general cognitive function is supported by a widespread white matter network across multiple brain regions and connectivity measures.

Epigenome-wide association study meta-analysis of wellbeing

This study conducts an epigenome-wide association study (EWAS) meta-analysis of wellbeing using DNA methylation data, finding no significant methylation sites but suggesting the need for larger studies.

Large-Scale Gene-Smoking Interactions and Fine Mapping Study Identifies Multiple Novel Blood Pressure Loci in over 1 Million Individuals

This study identifies twelve novel blood pressure loci and shows smoking modifies genetic effects on BP through immune-related pathways in over 1 million individuals.

Relative strength variability measures for brain structural connectomes and their relationship with cognitive functioning

This paper introduces new graph measures for brain structural connectomes, showing they better predict general cognitive function than existing measures.

Lifetime brain atrophy estimated from a single MRI: measurement characteristics and genome-wide correlates

This paper evaluates methods to estimate lifetime brain atrophy from a single MRI scan and identifies genetic correlates, finding that the residual method best captures brain shrinkage and has strong heritability.

Robust inference and widespread genetic correlates from a large-scale genetic association study of human personality

This study identifies 1,257 genetic variants associated with human personality traits using large-scale GWAS and finds widespread genetic correlations with behaviors and life outcomes.

Clinical progression of clonal hematopoiesis is determined by a combination of mutation timing, fitness, and clonal structure

The paper investigates how mutation timing, fitness, and clonal structure influence the clinical progression of clonal hematopoiesis using longitudinal cohort data.

Brain maps of general cognitive function and spatial correlations with neurobiological cortical profiles

The paper identifies brain regions most related to general cognitive function and links them to neurobiological properties using meta-analysis and multimodal cortical maps.

Interplay between polygenic effects and polypharmacy on dementia: An investigation in an elderly Scottish cohort.

The paper investigates the interaction between polygenic risk scores for Alzheimer's dementia and polypharmacy in predicting future dementia risk in an elderly Scottish cohort.

Genetic mechanisms of 184 neuro-related proteins in human plasma

The paper identifies genetic regulators of 184 neuro-related proteins in human plasma and links them to disease traits and drug targets.

Genetic variants for head size share genes and pathways with cancer

This study identifies 67 genetic loci associated with head size, finding strong overlaps with cancer pathways and genes, suggesting shared genetic mechanisms between head growth and cancer risk.

Copy-number variants and polygenic risk for intelligence confer risk for autism spectrum disorder irrespective of their effects on cognitive ability

This study shows that rare CNVs and PRS-IQ increase ASD risk independently of their effects on cognitive ability, suggesting ASD risk and cognitive ability are distinct outcomes of these variants.

General and specific patterns of cortical gene expression as substrates of complex cognitive functioning

The paper identifies general and specific patterns of cortical gene expression related to cognitive functioning using principal component analysis and validates them across datasets.

General dimensions of human brain morphometry inferred from genome-wide association data

This study uses genomic PCA to identify shared genetic architecture between brain morphometry, ageing, and cognitive ability using UK Biobank data.

Genome-wide analysis identifies genetic effects on reproductive success and ongoing natural selection at the FADS locus.

This study identifies 43 genomic loci associated with reproductive success in 785,604 individuals, showing ongoing natural selection at the FADS locus.

Rare Genetic Variants Underlie Outlying levels of DNA Methylation and Gene-Expression

This study identifies rare genetic variants associated with extreme DNA methylation levels and shows their impact on gene expression in healthy ageing populations.

Local CpG density affects the trajectory of age-associated epigenetic changes

The paper shows that local CpG density influences age-related DNA methylation changes in humans by analyzing longitudinal methylation data and SNP data from 600 individuals.

An integrative analysis of clinical and epigenetic biomarkers of mortality

The paper integrates DNA methylation with clinical risk factors to improve mortality prediction, identifying CpG biomarkers associated with all-cause, cardiovascular, and cancer mortality.

A comparison of blood and brain-derived ageing and inflammation-related DNA methylation signatures and their association with microglial burdens

This study compares DNA methylation signatures of ageing and inflammation in blood and brain tissues, finding divergent correlations and a link between epigenetic age acceleration and microglial burdens in the hippocampus.

Blood-based epigenome-wide analyses of cognitive abilities

This study identifies DNA methylation predictors of cognitive function using blood samples, showing they explain variance in cognitive ability and associate with biological markers.

Epigenetic scores for the circulating proteome as tools for disease prediction

The paper develops epigenetic scores (EpiScores) for plasma proteins to predict disease risk, finding 137 associations with incident morbidities independent of known factors.

Genome and epigenome wide studies of plasma protein biomarkers for Alzheimer's disease implicate TBCA and TREM2 in disease risk

The paper identifies genetic and epigenetic factors influencing plasma protein levels linked to Alzheimer's disease, finding novel associations with TREM2 and TBCA.

Association between plasma phospho-tau181 and cognitive change from age 73 to 82: Lothian Birth Cohort 1936

This study shows that higher plasma phospho-tau181 levels and their increase over time predict faster cognitive decline in older adults and are present in brain synapses.

Characterizing the human methylome across the life course: findings from eight UK-based studies

This study maps DNA methylation changes across the human life course using data from 7,037 individuals, showing increased variability and age-related mean changes at specific CpG sites.

Methylome-wide association study of early life stressors and adult mental health reveals a relationship between birth date and cell type composition in blood

This study investigates the relationship between early life stressors and adult mental health through methylome-wide association studies, finding no evidence of methylome mediation but linking birth date to blood cell type composition.

Identifying Nootropic Drug Targets via Large-Scale Cognitive GWAS and Transcriptomics

This paper identifies potential nootropic drug targets by integrating large-scale cognitive GWAS and transcriptomic data to find credible druggable genes.

Creating and validating a DNA methylation-based proxy for Interleukin-6

The paper develops a DNA methylation-based proxy for interleukin-6 and finds it correlates with age and cognitive functioning better than serum IL-6.

Three major dimensions of human brain cortical ageing in relation to cognitive decline across the 8th decade of life.

This study identifies three dimensions of cortical ageing in the human brain and links the most general dimension to cognitive decline across multiple domains in older adults.

Birth weight is associated with brain tissue volumes seven decades later, but not with age-associated changes to brain structure

The paper examines the association between birth weight and brain structure in older age, finding positive links with brain volumes but not with age-related structural changes.

Genome-wide association study identifies 48 common genetic variants associated with handedness.

This study identifies 48 genetic variants associated with handedness using a large GWAS, highlighting polygenic nature and genetic links to neuropsychiatric traits.