Eric Latorre Crespo

Clinical progression of clonal hematopoiesis is determined by a combination of mutation timing, fitness, and clonal structure

The paper investigates how mutation timing, fitness, and clonal structure influence the clinical progression of clonal hematopoiesis using longitudinal cohort data.

High-dimensional Ageome Representations of Biological Aging across Functional Modules

This paper introduces Ageome, a framework to measure epigenetic age across molecular pathways in mice and humans, revealing pathway-specific aging patterns and heterogeneity in mortality prediction.

DNA methylation rates scale with maximum lifespan across mammals

This study finds that DNA methylation rates negatively scale with maximum lifespan across mammals in blood and skin.

Region-Based Epigenetic Clock Design Improves RRBS-Based Age Prediction

This paper improves age prediction from RRBS data by using region-based methylation averages instead of individual CpGs, showing better performance on external datasets and low coverage data.