iPSC-derived neurons as a tool for probing molecular pharmacology of antipsychotic action.
Esther S. Kim, E. David Leonardo, Alex Dranovsky
This study demonstrates that iPSC-derived neurons express antipsychotic drug targets and respond to ligands, showing clozapine modulates glutamatergic and serotonergic responses in distinct neuronal populations.
bioRxiv · Apr 25, 2018 · PreprintPharmacology & Toxicology