Hypomineralized Enamel Alters Trigeminal Sensory Afferent Architecture, Transcriptome, and Dental Injury Responses
Hakan Karaaslan, Robert A. Bossong, Esther Wu, Lama Alabdulaaly, Min Son, Xuesong He, Isaac M. Chiu, Jennifer L. Gibbs, Felicitas B. Bidlack, Özge Erdoğan
This study shows that enamel hypomineralization alters dental pulp and trigeminal nerve structure, transcriptome, and injury response without direct pulp exposure.
bioRxiv · Sep 16, 2026 · PreprintNeuroscience