Xuesong He

A domesticated prophage enzyme links bacterial metabolism, episymbiosis and phage fitness

The paper identifies a prophage-encoded enzyme that links bacterial metabolism, episymbiosis, and phage fitness by remodeling host structures and promoting symbiotic interactions.

Host Cell Wall Polysaccharides Modulate Nanosynbacteria Recognition and Attachment

This study identifies adhesin proteins in Nanosynbacteria that recognize specific host cell wall polysaccharides for recognition and attachment.

Hypomineralized Enamel Alters Trigeminal Sensory Afferent Architecture, Transcriptome, and Dental Injury Responses

This study shows that enamel hypomineralization alters dental pulp and trigeminal nerve structure, transcriptome, and injury response without direct pulp exposure.

Profiling Gingival Inflammation in a 3D Oral Tissue Model Reveals Early Features of Disease Progression

This study uses a 3D oral tissue model to investigate early gingival inflammation and disease progression by analyzing host-microbiome interactions.

Dormant Bacteria's Fatal Attraction to RNA Bacteriophages

The paper shows RNA phages are eliminated in dormant bacteria via ROS-mediated damage, but survival depends on genomic redundancy through co-infection.

Identifying essential genes in Schaalia odontolytica using a highly-saturated transposon library

This study identifies essential genes in Schaalia odontolytica using high-throughput transposon insertion sequencing.

Episymbiotic Saccharibacteria suppresses epithelial immunoactivation through Type IV pili and TLR2 dependent endocytosis

This study shows Saccharibacteria suppress epithelial immune activation by clustering TLR2 via Type IV pili and endocytosis, reducing cytokine signaling and enabling long-term persistence in the oral microbiome.

Physiologically Relevant Coculture Model for Oral Microbial-Host Interactions

This paper introduces a coculture model that simulates oral oxygen gradients to study microbial-host interactions and antibiotic efficacy.

Saccharibacteria deploy two distinct Type IV pili, driving episymbiosis, host competition, and twitching motility

This study identifies two distinct Type IV pili in Saccharibacteria, showing their roles in host binding, competition, and motility.

Engineered Bacillus subtilis as oral probiotics to enhance clearance of blood lactate

This paper engineers Bacillus subtilis spores to deliver lactate oxidase to the gut, reducing blood lactate in mice without disrupting microbiota or organ function.

Adhesive interactions within microbial consortia can be differentiated at the single-cell level through expansion microscopy

This study uses expansion microscopy to differentiate adhesive interactions between microbial cells in biofilms at the single-cell level.

Identification of P-type ATPase as a bacterial transporter for host-derived small RNA

This study identifies a bacterial P-type ATPase transporter, PtaT, that specifically binds and mediates the uptake of host-derived tsRNAs in Fusobacterium nucleatum.