Isaac M. Chiu

Hypomineralized Enamel Alters Trigeminal Sensory Afferent Architecture, Transcriptome, and Dental Injury Responses

This study shows that enamel hypomineralization alters dental pulp and trigeminal nerve structure, transcriptome, and injury response without direct pulp exposure.

Adrenergic signaling coordinates distant and local responses to amputation in axolotl

This paper shows that adrenergic signaling coordinates systemic and local stem cell activation after amputation in axolotls, enhancing regeneration.

Gasdermin D is activated but does not drive neurodegeneration in SOD1G93A model of ALS: Implications for targeting pyroptosis

This study shows GSDMD is activated in ALS mice but its loss does not improve disease outcomes or reduce neuroinflammation.

Vagal TRPV1+ sensory neurons regulate myeloid cell dynamics and protect against influenza virus infection

This study shows TRPV1+ sensory neurons protect against influenza by modulating myeloid cell responses and reducing immunopathology.

Molecular basis for shifted receptor recognition by an encephalitic arbovirus

The paper identifies receptor-binding polymorphisms in WEEV that explain shifts in receptor dependencies and enable nonpathogenic strains to infect neurons.

The meninges host a unique compartment of regulatory T cells that bulwarks adult hippocampal neurogenesis

The paper identifies a unique population of regulatory T cells in the murine meninges that maintain brain homeostasis by suppressing interferon-gamma-producing lymphocytes and preventing hippocampal damage.

Neuronal-immune Axis Alters Pain and Sensory Afferent Damage During Dental Pulp Injury

This study shows that CGRP from sensory afferents modulates pain and immune responses in dental pulpitis by recruiting neutrophils and monocytes, affecting tissue damage and bacterial spread.

A collaboration between immune cells and the choroid plexus epithelium in brain inflammation

The paper shows the ChP acts as an immune organ in brain inflammation, with immune cell interactions and epithelial cell specialization regulating the barrier.

Induction of antiviral Interferon-Stimulated Genes (ISGs) by neuronal STING promotes the resolution of pain

The paper shows that neuronal STING activation induces IFN-stimulated genes, which resolve inflammatory pain through KChIP1-Kv4.3 regulation.

A DRG genetic toolkit reveals molecular, morphological, and functional diversity of somatosensory neuron subtypes

The paper develops a genetic toolkit to study DRG neuron subtypes, revealing their molecular, morphological, and functional diversity in response to mechanical and thermal stimuli.

Gasdermin-E mediates mitochondrial damage in axons and neurodegeneration

This study identifies GSDME as a mediator of mitochondrial damage and axon loss in neurodegenerative diseases, showing its role in ALS and FTD models.

Anthrax Toxin as a Molecular Platform to Target Nociceptive Neurons and Modulate Pain

This paper shows anthrax toxin can target and modulate pain by acting on nociceptive neurons through ANTXR2, with potential for new pain therapeutics.