Author

Ethan Shurberg

Broad Institute

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 1 Genomics· 1

Signature Assays, Organisms & Methods

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Research Focus:differential expression· 2 Research Focus:gene regulatory network inference· 2 Assay:ATAC-seq· 1 Assay:bulk RNA-seq· 1 Research Focus:cell type annotation· 1 Approach:deep learning· 1 Approach:experimental assay· 1 Organism:human· 1

Frequent Co-Authors

Akansha A. GuptaiD· 1 shared Anders B. DohlmaniD· 1 shared Daniel Denney· 1 shared David M. WalteriD· 1 shared Garrett Michael FramptoniD· 1 shared Iris TIENLYNN. LeeiD· 1 shared Jakob M. Heinz· 1 shared Jodi Lee· 1 shared

Activity by Year

2026-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 29 mutual co-author links

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1 shared paperCancer Biology

Akansha A. GuptaORCID

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2 papers

Recent·Most cited

ChAI-Net learns a regulatory code for chromatin co-accessibility

Jodi Lee, Kaite Zhang, Ethan Shurberg, Vijay S. Ramani, Katherine S. Pollard

The paper introduces ChAI-Net, a deep learning model that predicts chromatin co-accessibility from DNA sequences in mouse embryonic stem cells, revealing sequence motifs that govern coordinated TF binding.

bioRxiv · Oct 31, 2026 · PreprintGenomics

U2AF1 mutations rescue deleterious exon skipping induced by KRAS mutations

David M. Walter, Katherine Cho, Smruthy Sivakumar, Daniel Denney, Iris TIENLYNN. Lee, Anders B. Dohlman, Jakob M. Heinz, Ethan Shurberg, Kevin X. Jiang, Akansha A. Gupta, Garrett Michael Frampton, Matthew M. Meyerson

This study shows that U2AF1 mutations can rescue exon skipping caused by KRAS mutations in lung adenocarcinoma, revealing a dynamic interplay between splicing factor and oncogenic mutations.

Nature Genetics · Jul 1, 2026Peer-reviewedCancer Biology