Smruthy Sivakumar

The paper identifies increased GPCR pathway activity in breast cancer ovarian metastases and links it to migration and F-actin reorganization through CaSR.

The paper identifies Aurora kinase A as a synthetic lethal target in FANCA-deficient cancers and shows AURKA inhibition induces chromosomal instability and G2/M arrest in these cells.

This study shows that U2AF1 mutations can rescue exon skipping caused by KRAS mutations in lung adenocarcinoma, revealing a dynamic interplay between splicing factor and oncogenic mutations.

The paper identifies synthetic lethality between POLE exonuclease deficiency and high aneuploidy in cancer cells, suggesting POLE inhibition as a therapeutic strategy for aneuploid tumors.

The paper identifies reversion mutations in homologous recombination genes across cancers, showing they restore DNA repair and confer PARP inhibitor resistance through specific structural alterations.

The paper investigates tissue-specific chromosomal deletions in BRCA1/2-related cancers using bulk and single-cell data, finding early deletions of 17q and 13q in breast and ovarian cancers.

The paper develops machine learning models to predict pathogenicity of BRCA1 and BRCA2 variants using cancer genomic profiles, improving classification of variants of uncertain significance.

The paper investigates functional differences between EML4-ALK variants V1 and V3 in lung cancer using mouse models and human data, showing variant-specific effects on tumorigenesis.

The paper analyzes allelic imbalance across 33 tumor types using haplotype-based methods on TCGA data, finding high prevalence of AI and recurrent chromosomal aberrations.