Heterologous betacoronavirus spike immunization in nonhuman primates elicits cross-reactive antibodies that neutralize both sarbeco- and merbecoviruses
Katharina Dueker, Tazio Capozzola, Ziqi Feng, Ryan N. Lin, Jonathan Hurtado, Sandhya Bangaru, Meng Yuan, Nathan Beutler, Elijah Garcia, Wan-Ting He, Sean Callaghan, Gabriel Avillion, Lina Vo, Xuduo Li, Jonathan L. Torres, , Raiees Andrabi
This study vaccinates nonhuman primates with SARS-CoV-2 and MERS-CoV spike proteins to elicit cross-reactive antibodies that neutralize both sarbecoviruses and merbecoviruses.
bioRxiv · Jan 23, 2026 · PreprintImmunology