Wan-Ting He

Epitope-focused S2 stem-helix nanoparticle immunogens elicit protective broadly neutralizing antibodies against diverse betacoronaviruses in non-human primates, establishing a framework for pan-betacoronavirus vaccines.

This paper describes the directed evolution of an antibody to enhance its binding affinity for MERS-CoV, resulting in cross-neutralization against multiple betacoronaviruses.

This paper evaluates how gene tree dependence affects species tree inference accuracy using ASTRAL, finding that dependence reduces effective sample size but does not require full independence for accurate results.

This study vaccinates nonhuman primates with SARS-CoV-2 and MERS-CoV spike proteins to elicit cross-reactive antibodies that neutralize both sarbecoviruses and merbecoviruses.

This paper compares SARS-CoV-2 spike protein binding to ACE2 receptors across multiple species to identify key residues and assess host range and potential intermediate hosts.