Author

Tazio Capozzola

Scripps Research InstituteORCID 0000-0002-7269-588XUnclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Approach:experimental assay· 5 Research Focus:host-pathogen & immune response· 4 Organism:human· 2 Organism:non-human primate· 2 Assay:proteomics· 2 Organism:rat· 2 Research Focus:protein design· 1 Assay:protein structure· 1

Frequent Co-Authors

Dennis R. BurtoniD· 5 shared Gabriel AvillioniD· 5 shared Raiees AndrabiiD· 5 shared Sean CallaghaniD· 5 shared Xuduo LiiD· 5 shared Andrew B. WardiD· 4 shared Nitesh MishraiD· 4 shared Darrell J. IrvineiD· 3 shared

Activity by Year

2025-2026 · peak 4/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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5 shared papersImmunology

Dennis R. BurtonORCID

Mutual co-authors in cluster

Author profile →

5 papers

Recent·Most cited

Protective pan-betacoronavirus neutralizing antibodies by vaccination

Pan-Pan Zhou, Ziqi Feng, Wan-ting He, Yuxin Zhu, Meng Yuan, Xuduo Li, Yuexiu Zhang, Lina Vo, Tazio Capozzola, Sean Callaghan, Nitesh Mishra, Gabriel Avillion, Katharina Dueker, Bo Liang, Rohan Roy Chowdhury, , Raiees Andrabi

Epitope-focused S2 stem-helix nanoparticle immunogens elicit protective broadly neutralizing antibodies against diverse betacoronaviruses in non-human primates, establishing a framework for pan-betacoronavirus vaccines.

bioRxiv · Aug 7, 2026 · PreprintImmunology

Directed evolution of a stem-helix targeting antibody enables MERS-CoV cross-neutralization through enhanced binding affinity

Pan-Pan Zhou, Meng Yuan, Yuexiu Zhang, Oliver Limbo, Ge Song, Fangzhu Zhao, Hejun Liu, Wan-Ting He, Tazio Capozzola, Sean Callaghan, Gabriel Avillion, Xuduo Li, Nathan Beutler, Peter Yong, Fabio Anzanello, , Raiees Andrabi

This paper describes the directed evolution of an antibody to enhance its binding affinity for MERS-CoV, resulting in cross-neutralization against multiple betacoronaviruses.

PLoS Pathogens · Aug 7, 2026Peer-reviewedImmunology

Germline-targeting HIV immunogen induces cross-neutralizing antibodies in outbred macaques

Nitesh Mishra, Bo Liang, Ryan S. Roark, Amrit Raj Ghosh, Sean Callaghan, Wen-Hsin Lee, Xuduo Li, Anh L. Vo, Gabriel Avillion, Rohan Roy Chowdhury, Rumi Habib, Frédéric Bibollet‐Ruche, Gabriella Giese, Prabhgun Oberoi, Khaled Amereh, , Raiees Andrabi

This study shows that a germline-targeting HIV immunogen induces cross-neutralizing antibodies in outbred macaques by priming V2-apex bnAb B cell precursors.

Immunity · Apr 1, 2026Peer-reviewedImmunology

Heterologous betacoronavirus spike immunization in nonhuman primates elicits cross-reactive antibodies that neutralize both sarbeco- and merbecoviruses

Katharina Dueker, Tazio Capozzola, Ziqi Feng, Ryan N. Lin, Jonathan Hurtado, Sandhya Bangaru, Meng Yuan, Nathan Beutler, Elijah Garcia, Wan-Ting He, Sean Callaghan, Gabriel Avillion, Lina Vo, Xuduo Li, Jonathan L. Torres, , Raiees Andrabi

This study vaccinates nonhuman primates with SARS-CoV-2 and MERS-CoV spike proteins to elicit cross-reactive antibodies that neutralize both sarbecoviruses and merbecoviruses.

bioRxiv · Jan 23, 2026 · PreprintImmunology

Structure-guided design of native-like HIV Env Single Chain Trimers for enhanced stability, immunogenicity, and versatile vaccine delivery

Xuduo Li, Ipsita Krishnamurthy, Nitesh Mishra, Nicole E. James, Rohan Roy Chowdhury, Sean Callaghan, Anjali Somanathan, Gabriel Avillion, Khaled Amereh, Tharunika Sekar, Prabhgun Oberoi, Yuxin Zhu, Jonathan L. Torres, Wen-Hsin Lee, Joel D. Allen, , Raiees Andrabi

The paper designs native-like HIV Env single-chain trimers (SCTs) that are stable, immunogenic, and compatible with vaccine delivery methods.

bioRxiv · Oct 25, 2025 · PreprintImmunology