Discovery of the first small-molecule extracellular inhibitor of KCa3.1
Joana Massa, Jurek Hense, Tanja Gangnus, Matteo Gozzi, Etmar Bulk, Bjoern Bengt Burckhardt, Martina Düfer, Albrecht Schwab, Oliver Koch
This paper discovers a small-molecule inhibitor of KCa3.1 channels by combining molecular dynamics simulations and high-throughput screening.
bioRxiv · Mar 10, 2026 · PreprintPharmacology & Toxicology