Synergetic hallmark knockouts immortalize bovine muscle stem cells for cellular agriculture
Xiaoli Zhang, Benjamin H. Bromberg, Edward Gordon, Archana Nagarajan, Andrew J. Stout, Onur Hasturk, Davin Sim, Joy C. Brennan, Nadia D. La, Aneth J. Fernandez, Shlomit David, Eugene C. White, David Lee Kaplan
This study knocks out PTEN, TP53, and SMAD4 in bovine satellite cells to create an immortalized cell line that proliferates and differentiates into myotubes, supporting cellular agriculture applications.
bioRxiv · Sep 2, 2025 · PreprintCell Biology