Oncogenic ERK signaling represses chaperone-mediated autophagy through transcriptional control of LAMP-2A
Eva Berenger, Merve Kacal, Alice Maestri, Elena Y. Kochetkova, Boxi Zhang, Suresh Sajwan, Mattias Mannervik, Erik Norberg, Vitaliy O. Kaminskyy, Helin Vakifahmetoglu-Norberg
The paper identifies ERK signaling as a suppressor of chaperone-mediated autophagy (CMA) and shows that inhibiting ERK can restore CMA by increasing LAMP-2A expression.
bioRxiv · Mar 4, 2026 · PreprintCell Biology