COPS5 is Essential for Sertoli Cell Function and Male Fertility in Mice
Changmin Niu, Li Tao, Wei Li, Yi Tian Yap, Qian Huang, Lei Jiang, Opeyemi Dhikhirullahi, Ava Miciuda, Eva Faddoul, Shizheng Song, Michael D. Griswold, Zhibing Zhang
This study shows that COPS5 is essential for Sertoli cell function and male fertility in mice, as its loss causes infertility through disrupted cell polarity, blood-testis barrier integrity, and gap junction communication.
bioRxiv · Dec 22, 2025 · PreprintGenetics