Lei Jiang

The common evolution of fungicide persistence in cryptococcosis patients

The paper identifies common evolutionary events leading to fungicide persistence in Cryptococcus neoformans clinical isolates and shows ACO2 deficiency as a key predictor of high persistence.

Sphingosine kinase 2 suppresses neutrophil responses to promote viral persistence while attenuating immune pathology

This study shows that SphK2 deficiency in neutrophils reduces immune suppression, enhances T cell responses, and decreases viral persistence during LCMV infection.

COPS5 is Essential for Sertoli Cell Function and Male Fertility in Mice

This study shows that COPS5 is essential for Sertoli cell function and male fertility in mice, as its loss causes infertility through disrupted cell polarity, blood-testis barrier integrity, and gap junction communication.

PEFT-SP: Parameter-Efficient Fine-Tuning on Large Protein Language Models Improves Signal Peptide Prediction

PEFT-SP improves signal peptide prediction using parameter-efficient fine-tuning on large protein language models, achieving higher MCC2 gains with limited training data.

CellDiffusion: Enhancing scRNA-seq data integration with accurate inference of cell-cell association

CellDiffusion improves scRNA-seq data integration by accurately inferring cell-cell associations and correcting batch effects across diverse datasets.

Impacted Spike Frequency Adaptation Associated with Reduction of KCNQ2/3 Promotes Seizure Activity in Temporal Lobe Epilepsy

The paper identifies reduced KCNQ2/3 expression and impaired spike frequency adaptation in TLE patients and mouse models, showing their role in promoting seizure activity.