Erythroferrone Modulates Osteoblast-Osteoclast Crosstalk During Bone Remodeling
Pinanong Na-Phatthalung, Gabrielle van Caloen, Marina Planoutene, Emily Tai, Anisa Azatovna Gumerova, Georgii Pevnev, Jay Cao, Ronit Witztum, Eva Ingber, Léon Kautz, Farhath Sultana, Funda Korkmaz, Maayan Levy, Tony Yuen, Mone Zaidi, Yelena Z. Ginzburg
This study shows that osteoclast-derived erythroferrone (ERFE) regulates bone mass by modulating osteoblast-osteoclast communication, with ERFE loss in osteoclasts leading to increased osteoclastogenesis and bone loss.
bioRxiv · May 8, 2026 · PreprintCell Biology