This study shows that osteoclast-derived erythroferrone (ERFE) regulates bone mass by modulating osteoblast-osteoclast communication, with ERFE loss in osteoclasts leading to increased osteoclastogenesis and bone loss.

bioRxiv · May 8, 2026 · PreprintCell Biology

Sex-specific Single Transcript Level Atlas of Vasopressin and its Receptor (AVPR1a) in the Mouse Brain

Anisa Azatovna Gumerova, Georgii Pevnev, Funda Korkmaz, Uliana Cheliadinova, Guzel Burganova, Darya Vasilyeva, Liam Cullen, Orly Barak, Farhath Sultana, Weibin Zhou, Steven Lee Sims, Emily Weiss, Victoria Laurencin, Tal Frolinger, Se‐Min Kim, , Vitaly Ryu

The paper maps Avp and Avpr1a single transcript expression in the mouse brain to identify sex-specific neuronal nodes involved in AVP's role in social behaviors.

eLife · Mar 16, 2026Peer-reviewedNeuroscience

Single Transcript Level Atlas of Oxytocin and the Oxytocin Receptor in the Mouse Brain

Vitaly Ryu, Anisa Azatovna Gumerova, Georgii Pevnev, Funda Korkmaz, Hasni Suhasha Kannangara, Liam Cullen, Farhath Sultana, Ronit Witztum, Steven Lee Sims, Tal Frolinger, Ofer Moldavski, Orly Barak, Emily Weiss, J. J. Cao, Daria Lizneva, , Mone Zaidi

The paper maps OXT and OXTR expression in the mouse brain at the single transcript level to identify functional OXT nodes.

eLife · Feb 23, 2026Peer-reviewedPhysiology

An Atlas of Brain-Bone Sympathetic Neural Circuits

Vitaly Ryu, Anisa Azatovna Gumerova, Ronit Witztum, Funda Korkmaz, Liam Cullen, Hasni Suhasha Kannangara, Ofer Moldavski, Orly Barak, Daria Lizneva, Ki Ann Goosens, Sarah A. Stanley, Se‐Min Kim, Tony Yuen, Mone Zaidi

This paper identifies central brain regions that send sympathetic nervous system outflow to bone using viral tracing, revealing 87 brain sites and site-specific variations in neural control.

eLife · Jul 4, 2024Peer-reviewedNeuroscience

Gene-Dose-Dependent Reduction Fshr Expression Improves Spatial Memory Deficits in Alzheimer's Mice

Funda Korkmaz, Steven Lee Sims, Fazilet Şen, Farhath Sultana, Victoria Laurencin, Liam Cullen, Anusha Pallapati, Avi Liu, Satish V. Rojekar, George Penev, Ulliana Cheliadinova, Darya Vasilyeva, Guzel Burganova, Anne Macdonald, Mansi Saxena, , Mone Zaidi

This study shows that reducing Fshr expression in Alzheimer's mice improves spatial memory, with gene-dose-dependent effects, and links low FSH levels to better memory retrieval.

bioRxiv · Feb 16, 2024 · PreprintNeuroscience

Brain Atlas for Glycoprotein Hormone Receptors at Single-Transcript Level

Vitaly Ryu, Anisa Azatovna Gumerova, Funda Korkmaz, Seong Su Kang, Pavel Katsel, Sari Miyashita, Hasni Suhasha Kannangara, Liam Cullen, Pokman Chan, Tan‐Chun Kuo, Ashley Padilla, Farhath Sultana, Soleil A Wizman, Natan Kramskiy, Samir Zaidi, , Mone Zaidi

The paper creates a comprehensive neuroanatomical atlas of glycoprotein hormone receptor expression in the brain using single-transcript detection technologies.

eLife · Sep 2, 2022Peer-reviewedNeuroscience