Reductive carboxylation via isocitrate dehydrogenase 1 supports cardiac metabolic adaptation during oncometabolic stress.
Tanvi Shankar, Yaqi Gao, Zipporah Erebholo, Nicole Nakama, Kyoungmin Kim, Ian K. Williamson, Nathaniel Snyder, Evan Kransdorf, Ralph J. DeBerardinis, Heinrich Taegtmeyer, Brandon Faubert, Anja Karlstaedt
The paper investigates how IDH1 supports cardiac metabolic adaptation under oncometabolic stress by enabling reductive carboxylation and epigenetic changes.
bioRxiv · Oct 8, 2026 · PreprintSystems Biology