Anja Karlstaedt

This paper uses MALDI-MSI to create the first spatially resolved lipidomic atlas of the human heart, identifying region-specific lipid differences.

The paper investigates how IDH1 supports cardiac metabolic adaptation under oncometabolic stress by enabling reductive carboxylation and epigenetic changes.

This study introduces a shotgun single-cell top-down proteomics method to profile proteoform diversity in cardiomyocytes, revealing significant molecular heterogeneity across individual cells.

In db/db mice, six weeks of AZD1656 improved diastolic function, cardiac metabolism and infarct size, with increased Treg infiltration and less fibrosis, without glycaemic change.

This study maps metabolic changes in 12 organs of male and female mice across 5 ages, identifying sex-specific patterns and a metabolic aging clock.

This study shows that IFN-gamma signaling in cardiomyocytes causes metabolic changes in the heart, including increased glucose uptake and reduced oxidative phosphorylation, which resemble changes in aging and heart failure.

This study identifies unique cardiac metabolic adaptations in Egyptian fruit bats using metabolomics and computational modeling, revealing reliance on lipid oxidation and oxidative phosphorylation.

This study shows that ACL loss in the heart increases glucose oxidation and reduces citrate efflux, leading to metabolic remodeling and cardiac dysfunction.

This study identifies allele-specific metabolic differences in HCM mouse models, linking lipid metabolism to early-stage cardiac dysfunction.

This study identifies SLC25A1 as a dosage-dependent regulator of metabolic reprogramming and heart development, linking mitochondrial function to cardiac morphogenesis and congenital heart disease.

This study shows that D2-HG induces cachexia in mice by disrupting NAD+ homeostasis and autophagy, revealing metabolic vulnerabilities in skeletal muscle.

This study shows all three IP3R isoforms are required for endothelin-1-induced hypertrophic signaling in cardiomyocytes, with IP3Rs mediating positive inotropic effects and NFAT activation.