Heinrich Taegtmeyer

The paper investigates how IDH1 supports cardiac metabolic adaptation under oncometabolic stress by enabling reductive carboxylation and epigenetic changes.

This study shows that estrogen deficiency worsens diastolic dysfunction and energy metabolism in hypertensive female mice, with improvements seen when estrogen or its receptor agonists are administered.

This study shows that ACL loss in the heart increases glucose oxidation and reduces citrate efflux, leading to metabolic remodeling and cardiac dysfunction.

This study shows that D2-HG induces cachexia in mice by disrupting NAD+ homeostasis and autophagy, revealing metabolic vulnerabilities in skeletal muscle.

This study shows all three IP3R isoforms are required for endothelin-1-induced hypertrophic signaling in cardiomyocytes, with IP3Rs mediating positive inotropic effects and NFAT activation.