Multiscale modelling of drug-host-pathogen interaction: quantifying drug and immune contributions to treatment response
Alessandro Ravoni, Enrico Mastrostefano, Davide Moretti, E. Onofri, Francesca Pelusi, Aristides Dokoumetzidis, Evangelos Karakitsios, Salvatore DʼAgate, Alessandro Di Deo, Umberto Villani, Paolo Tieri, Filippo Castiglione, Oscar E. Della Pasqua
This paper develops a multiscale computational framework to simulate drug-host-pathogen interactions and quantifies the relative contributions of drug and immune responses to bacterial clearance in tuberculosis treatment.
bioRxiv · Sep 1, 2026 · PreprintSystems Biology