Author

Enrico Mastrostefano

Istituto per le Applicazioni del Calcolo Mauro PiconeORCID 0000-0002-0023-7943Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Bioinformatics· 1 Systems Biology· 1

Signature Assays, Organisms & Methods

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Organism:human· 2 Approach:statistical model· 2 Research Focus:benchmarking· 1 Research Focus:cell type annotation· 1 Research Focus:differential expression· 1 Research Focus:drug response / drug discovery· 1 Research Focus:gene regulatory network inference· 1 Approach:graph neural network· 1

Frequent Co-Authors

Filippo CastiglioneiD· 2 shared Paolo TieriiD· 2 shared Alessandro CelestiniiD· 1 shared Alessandro Di DeoiD· 1 shared Alessandro PalmaiD· 1 shared Alessandro RavoniiD· 1 shared Aristides DokoumetzidisiD· 1 shared Davide Moretti· 1 shared

Activity by Year

2019-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 33 mutual co-author links

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2 shared papersSystems Biology

Filippo CastiglioneORCID

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2 papers

Recent·Most cited

Systems BiologybioRxivPreprintSep 1, 2026

Multiscale modelling of drug-host-pathogen interaction: quantifying drug and immune contributions to treatment response

Alessandro Ravoni, Enrico Mastrostefano, Davide Moretti…·Oscar E. Della Pasqua

This paper develops a multiscale computational framework to simulate drug-host-pathogen interactions and quantifies the relative contributions of drug and immune responses to bacterial clearance in tuberculosis treatment.

DOI 10.64898/2026.08.30.744418

humanstatistical model

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BioinformaticsIEEE International Conference on Bioinformatics and Biomedicine (BIBM)Peer-reviewedNov 1, 2019

Critical nodes reveal peculiar features of human essential genes and protein interactome

Alessandro Celestini, Marco Cianfriglia, Enrico Mastrostefano…·Paolo Tieri

The paper identifies critical nodes in the human protein-protein interaction network that have the greatest impact on network fragmentation and compares their biological relevance to essential genes.

2 citations

humanprotein structure

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