Paolo Tieri

Multiscale modelling of drug-host-pathogen interaction: quantifying drug and immune contributions to treatment response

This paper develops a multiscale computational framework to simulate drug-host-pathogen interactions and quantifies the relative contributions of drug and immune responses to bacterial clearance in tuberculosis treatment.

Mechanotransduction and inflammation: an updated comprehensive representation

The paper provides a unified pathway representation of mechanotransduction and inflammation using SBML and network biology approaches, highlighting RAC1 as a potential therapeutic target.

BiCoN: Network-constrained biclustering of patients and omics data

BiCoN identifies patient subgroups and functional gene subnetworks by integrating network constraints with biclustering of omics data.

Critical nodes reveal peculiar features of human essential genes and protein interactome

The paper identifies critical nodes in the human protein-protein interaction network that have the greatest impact on network fragmentation and compares their biological relevance to essential genes.