HCFC1 and YY1 mediate recruitment of COMPASS and Integrator to initiate X chromosome inactivation.
Jeffrey Boeren, Beatrice F. Tan, Sarra Merzouk, Eveline Rentmeester, Rien van Haperen, Samuel Jesus Luchsinger-Morcelle, Cheryl Maduro, Richelle Rietdijk, Busra Goynuk, Wilfred F. J. van IJcken, Jeroen Demmers, Cristina Gontan, Hegias Mira-Bontenbal, Joost H. Gribnau
This study identifies HCFC1 and YY1 as factors that recruit COMPASS and Integrator complexes to initiate X chromosome inactivation by regulating Xist and its cis-regulatory elements.
bioRxiv · Sep 18, 2025 · PreprintMolecular Biology