Everett Labrecque

Unraveling the developmental heterogeneity within the human retina to reconstruct the continuity of retinal ganglion cell maturation and stage-specific intrinsic and extrinsic factors

The paper constructs a scRNA-seq atlas of human fetal retina to map retinal ganglion cell maturation trajectories and identify intrinsic and extrinsic factors across developmental stages.

Human retinal organoid single-cell atlas allows to reconstruct retinal development at high resolution and identify nature restricted transcriptional states in vitro

The paper constructs a single-cell atlas of human retinal organoids to study development and identify novel transcriptional states.

Single-cell transcriptome of retinal myeloid cells in response to transplantation of human neurons reveals reversibility of microglial activation

This study uses single-cell RNA sequencing to analyze retinal myeloid cell activation following human neuron transplantation, revealing reversible activation trajectories similar to disease-associated microglia.