Single-cell transcriptome of retinal myeloid cells in response to transplantation of human neurons reveals reversibility of microglial activation
Emil Kriukov, Anthony Mukwaya, Paul Francis Cullen, George Baldwin, Volha V. Malechka, Nasrin Refaian, Nikita Bagaev, Everett Labrecque, Sthavir Vinjamuri, Milica A. Margeta, Petr Y. Baranov
This study uses single-cell RNA sequencing to analyze retinal myeloid cell activation following human neuron transplantation, revealing reversible activation trajectories similar to disease-associated microglia.
bioRxiv · May 16, 2025 · PreprintNeuroscience