Emil Kriukov

A lifespan single-cell atlas of the human developing hippocampus benchmarks familial Alzheimer's disease brain organoids.

The paper constructs a lifespan single-cell atlas of the human developing hippocampus and benchmarks iPSC-derived brain organoids with a PSEN1 mutation linked to familial Alzheimer's disease.

Improvement of human donor retinal ganglion cell survival through modulation of microglia

This study improves human donor retinal ganglion cell survival by modulating host microglia using annexin V and soluble Fas ligand, increasing survival by 2.5-fold.

Quantitative assessment of cell fate commitment in single-cell transcriptomics using scCS

The paper introduces scCS, a framework for quantifying cell fate commitment parameters in single-cell transcriptomics, using methods like DFFP and providing diagnostics and visualizations.

Adrenergic signaling coordinates distant and local responses to amputation in axolotl

This paper shows that adrenergic signaling coordinates systemic and local stem cell activation after amputation in axolotls, enhancing regeneration.

Unraveling the developmental heterogeneity within the human retina to reconstruct the continuity of retinal ganglion cell maturation and stage-specific intrinsic and extrinsic factors

The paper constructs a scRNA-seq atlas of human fetal retina to map retinal ganglion cell maturation trajectories and identify intrinsic and extrinsic factors across developmental stages.

Human retinal organoid single-cell atlas allows to reconstruct retinal development at high resolution and identify nature restricted transcriptional states in vitro

The paper constructs a single-cell atlas of human retinal organoids to study development and identify novel transcriptional states.

Single-cell transcriptome of retinal myeloid cells in response to transplantation of human neurons reveals reversibility of microglial activation

This study uses single-cell RNA sequencing to analyze retinal myeloid cell activation following human neuron transplantation, revealing reversible activation trajectories similar to disease-associated microglia.

Suppressing DNMT3a Alleviates the Intrinsic Epigenetic Barrier for Optic Nerve Regeneration and Restores Vision in Adult Mice

This study identifies DNMT3a as a key inhibitor of optic nerve regeneration in adult mice and shows that its suppression restores vision after injury.