Inhibition of CRISPR-Cas12a DNA Targeting by Nucleosomes and Chromatin
I. Strohkendl, F. A. Saifuddin, B. A. Gibson, M. K. Rosen, R. Russell, I. J. Finkelstein
This study shows that nucleosomes inhibit CRISPR-Cas12a binding and cleavage, with DNA unwrapping enhancing accessibility and cleavage rates.
bioRxiv · Jul 18, 2020Biochemistry