Characterization of antimalarial activity of artemisinin-based hybrid drugs
D. R. M. Moreira, H. C. Quadros, L. Herrmann, J. Manaranche, L. Paloque, M. C. Borges-Silva, G. A. Dziwornu, S. D'Alessandro, K. Chibale, N. Basilico, F. Benoit-Vical, S. Tsogoeva
This study characterizes the antimalarial activity of two artemisinin-based hybrid drugs against drug-sensitive and resistant Plasmodium falciparum parasites, finding that slow peroxide bond homolysis correlates with increased efficacy against resistant strains.
bioRxiv · Jan 26, 2024Microbiology