Redefining the role of Hypoxia-inducible factors (HIFs) in oxygen homeostasis
C. Fernandez Arias, F. J. Acosta, F. Bertocchini, C. Fernandez-Arias
This paper challenges the conventional view of HIFs as mediators of hypoxic stress, proposing instead that HIFs prevent hypoxia by regulating electron transport and redefining the Warburg effect as a homeostatic response to metabolic demand.
bioRxiv · Mar 15, 2024Cell Biology