Cryo-EM structure of cardiac amyloid fibrils from an immunoglobulin light chain (AL) amyloidosis patient
P. Swuec, F. Lavatelli, M. Tasaki, C. Paissoni, P. Rognoni, M. Maritan, F. Brambilla, P. Milani, P. Mauri, C. Camilloni, G. Palladini, G. Merlini, S. Ricagno, M. Bolognesi
The paper reports the cryo-EM structure of cardiac amyloid fibrils from an AL amyloidosis patient, revealing key structural features of the light chain variable domain involved in fibril formation.
bioRxiv · Oct 17, 2018Biochemistry