S. Ricagno

Endolysin B: A new archetype in M. tuberculosis treatment

This study demonstrates that Ms6LysB can impair M. tuberculosis growth and retain lytic properties when internalized by macrophages, suggesting its potential as a new therapeutic strategy.

Nanobodies counteract the toxicity of an amyloidogenic light chain by stabilizing a partially open dimeric conformation

This study identifies nanobodies that counteract the toxicity of an amyloidogenic light chain by stabilizing a partially open dimeric conformation, revealing insights into toxicity mechanisms.

The acidic intrinsically disordered region of the inflammatory mediator HMGB1 mediates fuzzy interactions with chemokine CXCL12

This study identifies the acidic intrinsically disordered region of HMGB1 as critical for forming a dynamic fuzzy heterocomplex with CXCL12, which enhances inflammatory signaling through CXCR4.

AbNatiV: VQ-VAE-based assessment of antibody and nanobody nativeness for hit selection, humanisation, and engineering

AbNatiV assesses antibody and nanobody nativeness using a VQ-VAE model, enabling hit selection, humanisation, and engineering with improved performance over conventional methods.

Cryo-EM Structure of a Mammalian-specific Alternative Amyloid Exon

The paper presents the cryo-EM structure of hnRNPDL-2 amyloid fibrils, showing how alternative splicing controls RNP assembly through an amyloid exon.

Goat PRP14 (gPRP14) has xeno-antigenic properties and works as a vaccine in preclinical models of cancer.

This study characterizes gPRP14 as a tumor-specific xeno-antigen that induces anti-tumor immunity in preclinical cancer models.

Cryo-EM structure of ex vivo fibrils associated with extreme AA amyloidosis prevalence in a cat shelter

The paper presents a cryo-EM structure of AA amyloid fibrils from a cat with renal failure, revealing a distinct amyloid fold despite high sequence homology to human and mouse SAA.

AA-amyloidosis in cats (Felis catus) housed in shelters

The paper reports high prevalence of AA-amyloidosis in sheltered cats, linking shelter stay duration to disease severity and identifying SAA as the causative protein.

Multi-eGO: an in-silico lens to look into protein aggregation kinetics at atomic resolution

The paper introduces multi-eGO, a computational model that simulates protein aggregation kinetics at atomic resolution, showing agreement with experimental data on Transthyretin peptides.

Conformational stability and dynamics in crystals recapitulate protein behaviour in solution

This study shows that conformational dynamics and stability of β2m in crystals mirror its behavior in solution, supporting the use of crystals for studying protein unfolding and aggregation.

Cryo-EM structure of cardiac amyloid fibrils from an immunoglobulin light chain (AL) amyloidosis patient

The paper reports the cryo-EM structure of cardiac amyloid fibrils from an AL amyloidosis patient, revealing key structural features of the light chain variable domain involved in fibril formation.