P. Milani

Nanobodies counteract the toxicity of an amyloidogenic light chain by stabilizing a partially open dimeric conformation

This study identifies nanobodies that counteract the toxicity of an amyloidogenic light chain by stabilizing a partially open dimeric conformation, revealing insights into toxicity mechanisms.

Cryo-EM structure of ex vivo fibrils associated with extreme AA amyloidosis prevalence in a cat shelter

The paper presents a cryo-EM structure of AA amyloid fibrils from a cat with renal failure, revealing a distinct amyloid fold despite high sequence homology to human and mouse SAA.

The glycocalyx affects the mechanotransductive perception of the topographical microenvironment

This study shows that glycocalyx configuration influences mechanotransductive responses of PC12 cells to nanotopographical cues through changes in actin dynamics and force loading.

Adhesion force spectroscopy with nanostructured colloidal probes reveals nanotopography-dependent early mechanotransductive interactions at the cell membrane level

This study uses adhesion force spectroscopy with nanostructured colloidal probes to show that nanotopography influences early mechanotransductive interactions by modulating force loading and integrin clustering in cell adhesion.

Cryo-EM structure of cardiac amyloid fibrils from an immunoglobulin light chain (AL) amyloidosis patient

The paper reports the cryo-EM structure of cardiac amyloid fibrils from an AL amyloidosis patient, revealing key structural features of the light chain variable domain involved in fibril formation.

Neuronal Cells Confinement by Micropatterned Cluster-Assembled Dots with Mechanotransductive Nanotopography

This paper develops micropatterned substrates with nanotopographical features to confine and guide neuronal cell growth and differentiation through mechanotransductive signaling.