Author

F. Bumbak

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biophysics· 2 Biochemistry· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Research Focus:protein folding & dynamics· 2 Approach:biophysical modeling· 1 Assay:proteomics· 1

Frequent Co-Authors

A. Inoue· 3 shared J. J. Ziarek· 3 shared S. A. ROBSON· 3 shared D. J. Scott· 2 shared F. Yan· 2 shared H. Wu· 2 shared J. C. Paniagua· 2 shared M. Pons· 2 shared

Activity by Year

2021-2022 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 39 mutual co-author links

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3 shared papersBiophysics

A. Inoue

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3 papers

Recent·Most cited

The dynamic nature of neurotensin receptor 1 (NTS1) allostery and signaling bias

F. Bumbak, A. Inoue, M. Pons, J. C. Paniagua, F. Yan, H. Wu, S. A. ROBSON, R. A. D. Bathgate, D. J. Scott, P. R. Gooley, J. J. Ziarek

This study investigates NTS1 allostery and signaling bias using NMR, showing PIP2 enhances transducer complexation through allosteric connections and β-arrestin modulates receptor conformation.

bioRxiv · Nov 25, 2022Biochemistry

Ligands tune the local and global motions of neurotensin receptor 1 (NTS1): a DFT-guided solution NMR analysis

F. Bumbak, M. Pons, A. Inoue, J. C. Paniagua, F. Yan, H. Wu, S. A. ROBSON, R. Bathgate, D. J. Scott, P. R. Gooley, J. J. Ziarek

This study uses NMR and DFT to analyze sub-nanosecond motions of NTS1, showing ligands affect conformational entropy and dynamics.

bioRxiv · Aug 9, 2022Biophysics

The Effect of Ligands and Transducers on the Neurotensin Recep-tor 1 (NTS1) Conformational Ensemble

A. D. Dixon, A. Inoue, S. A. ROBSON, K. Culhane, J. Trinidad, S. Sivaramakrishnan, F. Bumbak, J. J. Ziarek

This study uses 19F-NMR to show ligands and transducers modulate NTS1 conformational substates, revealing dynamic behavior not captured by static structures.

bioRxiv · Dec 8, 2021Biophysics