Author

S. Sivaramakrishnan

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biophysics· 4

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Organism:human· 2 Research Focus:protein folding & dynamics· 2 Approach:biophysical modeling· 1 Research Focus:cell signaling & trafficking· 1 Assay:proteomics· 1

Frequent Co-Authors

C. M. Yengo· 2 shared D. V. Rasicci· 2 shared F. R. Sadler· 2 shared A. D. Dixon· 1 shared A. Inoue· 1 shared A. M. Touma· 1 shared A. Rai· 1 shared D. M. Warshaw· 1 shared

Activity by Year

2021-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 19 mutual co-author links

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2 shared papersBiophysics

C. M. Yengo

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4 papers

Recent·Most cited

Cellular Lipids Regulate the Conformational Ensembles of the Disordered Intracellular Loop 3 in beta-2 Adrenergic Receptor

E. Mukhaleva, T. Yang, F. R. Sadler, S. Sivaramakrishnan, N. Ma, N. Vaidehi

This study shows that lipids like PIP2 and GM3 modulate the conformation of ICL3 in beta-2AR, affecting G protein coupling through membrane tilting and allosteric effects.

bioRxiv · Nov 28, 2023Biophysics

Dissecting β-Cardiac Myosin and Cardiac Myosin-Binding Protein C Interactions using a Nanosurf Assay

A. M. Touma, W. Tang, D. V. Rasicci, D. Vang, A. Rai, S. B. Previs, D. M. Warshaw, C. M. Yengo, S. Sivaramakrishnan

This study develops a nanosurf assay to investigate cMyBP-C interactions with actin and myosin, revealing that cMyBP-C inhibits actomyosin motility and that the M-domain and phosphorylation status are critical for this effect.

bioRxiv · Mar 11, 2022 · PreprintBiophysics

Dilated cardiomyopathy mutation E525K in human beta-cardiac myosin stabilizes the interacting heads motif and super-relaxed state of myosin

D. V. Rasicci, P. Tiwari, R. Desetty, F. R. Sadler, S. Sivaramakrishnan, R. Craig, C. M. Yengo

This study shows that the E525K mutation in human beta-cardiac myosin stabilizes the super-relaxed state and interacting-heads motif, potentially reducing muscle force and power.

bioRxiv · Feb 18, 2022 · PreprintBiophysics

The Effect of Ligands and Transducers on the Neurotensin Recep-tor 1 (NTS1) Conformational Ensemble

A. D. Dixon, A. Inoue, S. A. ROBSON, K. Culhane, J. Trinidad, S. Sivaramakrishnan, F. Bumbak, J. J. Ziarek

This study uses 19F-NMR to show ligands and transducers modulate NTS1 conformational substates, revealing dynamic behavior not captured by static structures.

bioRxiv · Dec 8, 2021Biophysics