The nucleus measures shape deformation for cellular proprioception and regulates adaptive morphodynamics
V. Venturini, F. Pezzano, F. Catala Castro, H.-M. Häkkinen, S. Jimenez-Delgado, M. Colomer-Rosell, M. Marro Sanchez, Q. Tolosa-Ramon, S. Paz-Lopez, M. A. Valverde, P. Loza-Alvarez, M. Krieg, S. Wieser, V. Ruprecht
The paper shows the nucleus acts as a shape deformation sensor, enabling cells to adapt behavior to their microenvironment through calcium-dependent mechano-transduction.
bioRxiv · Dec 5, 2019 · PreprintCell Biology