Optogenetic dissection of Rac1 and Cdc42 gradient shaping
S. de Beco, K. Vaidziulyte, J. Manzi, F. Dalier, F. Di Frederico, G. Cornilleau, M. Dahan, M. Coppey
This study uses optogenetics and micropatterning to show that Cdc42 and Rac1 gradients in migrating cells are shaped by spatial patterns of activators and deactivators, not advection or diffusion, and that gradient extent, not slope or amplitude, controls cell migration.
bioRxiv · May 8, 2018Cell Biology