Author

S. De Beco

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biophysics· 3 Cell Biology· 2

Signature Assays, Organisms & Methods

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Research Focus:cell signaling & trafficking· 5 Research Focus:development & morphogenesis· 4 Approach:experimental assay· 4 Research Focus:cell type annotation· 2 Assay:imaging· 2 Approach:statistical model· 2 Assay:fluorescence / live-cell microscopy· 1 Assay:metabolomics· 1

Frequent Co-Authors

M. Coppey· 3 shared B. Ladoux· 2 shared C. T. Lim· 2 shared G. Cornilleau· 2 shared J. D'Alessandro· 2 shared M. Dahan· 2 shared A. Gautreau· 1 shared A. Kabla· 1 shared

Activity by Year

2017-2020 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 19 mutual co-author links

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3 shared papersBiophysics

M. Coppey

Mutual co-authors in cluster

Author profile →

5 papers

Recent·Most cited

Endosomal spatio-temporal modulation of the cortical RhoA zone conditions epithelial cell organization

C. Gaston, S. De Beco, B. Doss, P. Meng, E. Gauquelin, J. D'Alessandro, C. T. Lim, B. Ladoux, D. Delacour

This study shows EpCAM regulates RhoA trafficking via endosomes to control actomyosin dynamics, cell shape, and polarity in epithelial cells.

bioRxiv · Apr 19, 2020Cell Biology

Emergence of single cell mechanical behavior and polarity within epithelial monolayers drives collective cell migration

S. Jain, V. Cachoux, G. Sankara, S. de Beco, J. D'Alessandro, V. Cellerin, T. Chen, M. Heuze, P. Marcq, R.-M. Mege, A. Kabla, C. T. Lim, B. Ladoux

This study shows that collective cell migration in epithelial monolayers arises from single-cell polarity signals rather than cell-cell junctions.

bioRxiv · Dec 16, 2019 · PreprintBiophysics

Stick-slip dynamics of cell adhesion triggers spontaneous symmetry breaking and directional migration

K. Hennig, I. Wang, P. Moreau, L. Valon, S. De Beco, M. Coppey, Y. Miroshnikova, C. Albiges Rizo, C. Favard, R. Voituriez, m. Balland

Cells break symmetry through mechanical instabilities causing stochastic adhesion detachment, initiating migration without pre-established polarity.

bioRxiv · Jun 25, 2018Biophysics

Optogenetic dissection of Rac1 and Cdc42 gradient shaping

S. de Beco, K. Vaidziulyte, J. Manzi, F. Dalier, F. Di Frederico, G. Cornilleau, M. Dahan, M. Coppey

This study uses optogenetics and micropatterning to show that Cdc42 and Rac1 gradients in migrating cells are shaped by spatial patterns of activators and deactivators, not advection or diffusion, and that gradient extent, not slope or amplitude, controls cell migration.

bioRxiv · May 8, 2018Cell Biology

Gradients Of Rac1 Nanoclusters Support Spatial Patterns Of Rac1 Signaling

A. Remorino, S. De Beco, F. Cayrac, F. Di Federico, G. Cornilleau, A. Gautreau, M. C. Parrini, J.-B. Masson, M. Dahan, M. Coppey

The paper shows Rac1 forms nanoclusters that create spatial gradients supporting Rac1 activity patterns in cell migration.

bioRxiv · Apr 28, 2017Biophysics