Cooperativity of catalytic and lectin-like domain of T. congolense trans-sialidase modulates its catalytic activity
M. Waespy, T. T. Gbem, N. Dinesh Kumar, S. Solaiyappan Mani, J. Rosenau, F. Dietz, S. Kelm
This study shows that the lectin domain of T. congolense trans-sialidase modulates its catalytic activity by favoring trans-sialylation over hydrolysis when interacting with specific carbohydrates.
bioRxiv · May 28, 2021Biochemistry