The endoplasmic reticulum stress sensor IRE1 regulates collagen secretion through the enforcement of the proteostasis factor P4HB/PDIA1 contributing to liver damage and fibrosis
Y. Hazari, H. Urra, V. A. G. Lopez, J. Diaz, G. Tamburini, M. Milani, P. Pihan, S. Durand, F. Aprahamia, R. Baxter, M. Huang, X. C. Dong, H. Vihinen, A. B. Gonzalez, P. Godoy, , C. Hetz
This study shows that IRE1 regulates collagen secretion via P4HB, contributing to liver fibrosis in models of CCl4 and high fat diet.
bioRxiv · May 2, 2023 · PreprintCell Biology