J. Diaz

Plasticity, geographic variation and trait coordination in blue oak drought physiology

The paper examines trait coordination and geographic variation in blue oak drought physiology, finding limited ecotypic variation but significant phenotypic integration in the wild.

The unfolded protein response transcription factor XBP1s ameliorates Alzheimer`s disease by improving synaptic function and proteostasis

This study shows that overexpressing the active form of XBP1 in neurons reduces amyloid deposits and improves synaptic function in Alzheimer's disease models.

The endoplasmic reticulum stress sensor IRE1 regulates collagen secretion through the enforcement of the proteostasis factor P4HB/PDIA1 contributing to liver damage and fibrosis

This study shows that IRE1 regulates collagen secretion via P4HB, contributing to liver fibrosis in models of CCl4 and high fat diet.

Identifying cell culturing parameters that improve endocytic uptake of the HIV-TAT cell penetrating peptide

This study identifies cell culturing parameters that significantly affect the endocytic uptake of the HIV-TAT cell-penetrating peptide, showing that small variations in protocols can lead to over 13-fold changes in uptake.

Microwell-Based Flow Culture Increases Viability and Restores Drug Response in Prostate Cancer Spheroids

This study introduces a Microwell Flow Device that improves spheroid viability and drug response in prostate cancer models by reducing hypoxia-related necrosis.

Information Flow in the Fibroblast Growth Factor Receptor Communication Channel

The paper models the FGFR communication channel's information flow through the MAPK cascade and GRN, finding that sustained FGF signals and low-frequency inputs affect gene regulation and cell cycle progression.

B cells adapt their nuclear morphology to organize the immune synapse and help antigen extraction

This study shows that B cells adapt nuclear morphology to organize the immune synapse and facilitate antigen extraction by repositioning the nucleus and coordinating actin and lysosome dynamics.

Ecm29-dependent proteasome localization regulates cytoskeleton remodeling at the immune synapse

This study shows that Ecm29 regulates proteasome localization, which in turn controls actin dynamics and lysosome positioning during immune synapse formation in B cells.

Sequential development of embryoblast-like memory entities in human cancer tissues: An evolutionary self-repair structure with pluripotentiality

The paper identifies embryoblast-like memory entities in human cancer tissues that exhibit pluripotentiality and self-repair capabilities, suggesting potential for regenerative medicine and targeted therapies.

Ctdnep1 and Eps8L2 regulate dorsal actin cables for nuclear positioning during cell migration

Enhanced translation expands the endo-lysosome size and promotes antigen presentation during phagocyte activation

This study identifies mTORC1-dependent translation as a mechanism for endo-lysosome expansion and antigen presentation during phagocyte activation.