E. Jokitalo

Ribosome-binding protein 1, RRBP1, maintains peroxisomal biogenesis

This study identifies RRBP1 as a novel peroxisome biogenesis factor in human cells, showing it promotes peroxisome formation and stabilizes peroxisomal proteins.

Progression of herpesvirus infection remodels mitochondrial organization and metabolism

This study shows how herpesvirus infection alters mitochondrial structure and metabolism during infection progression.

Peroxisomal tail-anchored proteins do not reach peroxisomes via ER, instead mitochondria can be involved.

This study shows that peroxisomal tail-anchored proteins do not enter the ER but may use mitochondria as an intermediate for their targeting to peroxisomes.

The endoplasmic reticulum stress sensor IRE1 regulates collagen secretion through the enforcement of the proteostasis factor P4HB/PDIA1 contributing to liver damage and fibrosis

This study shows that IRE1 regulates collagen secretion via P4HB, contributing to liver fibrosis in models of CCl4 and high fat diet.

Golgi organization is a determinant of stem cell function in the small intestine

This study shows that Lgr5+ stem cells in the small intestine adjust their Golgi apparatus orientation to enhance niche signal reception and tissue regeneration, which is impaired with age.

Global analysis of aging-related protein structural changes uncovers enzyme polymerization-based control of longevity

The paper identifies age-related protein structural changes in yeast and shows that inhibiting polymerization of glutamate synthase extends lifespan.

Seipin traps triacylglycerols to facilitate their nanoscale clustering in the ER membrane

This study shows seipin traps triacylglycerols in the ER membrane via its luminal hydrophobic helices, facilitating their nanoscale clustering and promoting TAG transfer to lipid droplets.

DeepMIB: User-friendly and open-source software for training of deep learning network for biological image segmentation

DeepMIB is a user-friendly, open-source tool for training deep learning networks to segment 2D and 3D biological images from light and electron microscopy.

Myosin-X and talin modulate integrin activity at filopodia tips

The paper identifies MYO10 and talin as key regulators of integrin activity in filopodia, proposing a two-step model for integrin activation.

Computational tools for serial block EM reveal differences in plasmodesmata distributions and wall environments

The paper develops computational tools for serial block electron microscopy to analyze plasmodesmata distribution and wall environment in Arabidopsis thaliana roots.

B cells rapidly target antigen and surface-derived MHCII into peripheral degradative compartments.

This study identifies specialized early peripheral acidic vesicles (eMIIC) in B cells that facilitate rapid antigen processing and MHCII peptide loading for immune response.

Dynamic-ultrastructural cell volume (3D) correlative microscopy facilitated by intracellular fluorescent nanodiamonds as multi-modal probes

This paper introduces a method using fluorescent nanodiamonds for 3D correlative light and electron microscopy to align multi-modal cell imaging data.