Macrophages and glia are the dominant P2X7-expressing cell types in the gut nervous system - no evidence for a role of neuronal P2X7 receptors in colitis
T. Jooss, J. Zhang, T. Rezzonico-Jost, B. Rissiek, F. Koch-Nolte, T. Magnus, S. Zierler, M. Schemann, F. Grassi, A. Nicke
The paper investigates P2X7 receptor expression in the gut nervous system, finding it primarily in macrophages and glia rather than neurons, and suggests these cells mediate P2X7 effects in IBD.
bioRxiv · Feb 2, 2022Physiology