A. Nicke

eATP/P2X7R axis drives nanoparticle induced neutrophil recruitment in the pulmonary microcirculation

This study identifies the eATP/P2X7R axis as a driver of nanoparticle-induced neutrophil recruitment in the pulmonary microcirculation using intravital microscopy in mice.

Voltage clamp fluorometry analysis of the P2X7 receptor suggests a limited conformational interplay between extracellular ATP binding and the intracellular ballast domain

Macrophages and glia are the dominant P2X7-expressing cell types in the gut nervous system - no evidence for a role of neuronal P2X7 receptors in colitis

The paper investigates P2X7 receptor expression in the gut nervous system, finding it primarily in macrophages and glia rather than neurons, and suggests these cells mediate P2X7 effects in IBD.

The molecular appearance of native TRPM7 channel complexes identified by high-resolution proteomics

The paper identifies native TRPM7 channel complexes in rodent brain using proteomics and confirms their functional relevance through reconstitution experiments.

A P2rx7 passenger mutation affects the vitality and function of immune cells in P2X4ko and other transgenic mice

The paper identifies a P2rx7 passenger mutation in 129-derived transgenic mice that affects T cell vitality and function, increasing sensitivity to NAD-induced cell death.