Membrane cholesterol interferes with tyrosine phosphorylation but facilitates the clustering and signal transduction of EGFR
M. Hiroshima, M. Abe, N. Tomishige, F. Hullin-Matsuda, A. Makino, M. Ueda, T. Kobayashi, Y. Sako
This study shows that cholesterol affects EGFR mobility, clustering, and signaling by altering membrane subdomain structure and lipid composition.
bioRxiv · Aug 28, 2021 · PreprintBiophysics