A. Makino

A non-toxic equinatoxin-II reveals the dynamics of sphingomyelin in the cytosolic leaflet of the plasma membrane

The paper uses a non-toxic SM probe to show dynamic SM and cholesterol domains in the cytosolic leaflet of plasma membranes.

Genome-scale CRISPR-Cas9 screen identifies novel host factors as potential therapeutic targets for SARS-CoV-2 infection.

The paper identifies TRIM28, TRIM33, EHMT1, and EHMT2 as novel host factors involved in SARS-CoV-2 infection and shows that EHMT1/2 inhibition reduces viral growth and disease severity.

Contact-number-driven virus evolution: a multi-level modeling framework for the evolution of acute or persistent RNA virus infection

This study models virus evolution under different contact histories, finding that high-contact environments favor acute infections while low-contact environments favor persistent infections.

Ban on wild bird importation accelerated the spread of global viral outbreaks in parrots.

This study shows that a ban on wild bird imports in the EU increased captive parrot trade, facilitating the global spread of PaBV-4, a lethal parrot virus.

Membrane cholesterol interferes with tyrosine phosphorylation but facilitates the clustering and signal transduction of EGFR

This study shows that cholesterol affects EGFR mobility, clustering, and signaling by altering membrane subdomain structure and lipid composition.

Manganese toxicity disrupts indole acetic acid homeostasis and suppresses CO2 assimilation reaction in rice plants

This study shows that manganese toxicity in rice reduces indole acetic acid levels, impairing stomatal function and CO2 assimilation, leading to growth defects.