Mechanisms for zinc and proton inhibition of the GluN1/GluN2A NMDA receptor
F. Jalali-Yazdi, S. Chowdhury, C. Yoshioka, E. Gouaux
This study uses cryo-EM to determine the structure of the GluN1/GluN2A NMDAR under varying zinc and proton concentrations, revealing how zinc binding affects channel gating.
bioRxiv · Jul 26, 2018Biophysics