S. Chowdhury

Identification of Novel Reproducible Combinatorial Genetic Risk Factors for Myalgic Encephalomyelitis in the DecodeME Patient Cohort and Commonalities with Long COVID

This paper identifies 22,411 reproducible genetic signatures associated with ME in DecodeME cohorts and finds significant overlap with long COVID genes, suggesting shared mechanisms but distinct diseases.

Impedance-based assay for pan-cancer early and rapid detection of cell-free DNA

This paper introduces an impedance-based biosensor for rapid, label-free detection of cancer-associated cfDNA with high sensitivity and specificity across multiple cancer types.

Flexible reproductive seasonality in Africa-dwelling papionins is associated with low environmental productivity and high climatic unpredictability

This study examines reproductive seasonality in Africa-dwelling papionins, finding that rainfall unpredictability, not rainfall seasonality, predicts the intensity of reproductive seasonality across populations.

Chloroquine attenuates hypoxia-mediated autophagy to curb thrombosis- an ex vivo and in vivo study

This paper shows chloroquine inhibits hypoxia-induced autophagy in platelets, reducing thrombosis in both ex vivo and in vivo models.

Senolytic CAR T cells reverse aging-associated defects in intestinal regeneration and fitness

This study shows that senolytic CAR T cells remove senescent cells in the aging gut, improving intestinal regeneration and immune function.

Conserved interfaces mediate multiple protein-protein interactions in a prokaryotic metabolon

This study maps 1225 protein-protein interactions in E. coli's 1-carbon metabolism pathway, revealing conserved interfaces that mediate transient interactions and enhance metabolic flux.

S-nitrosylation of EZH2 at C329 and C700 interplay with PRC2 complex assembly, methyltransferase activity, and EZH2 stability to regulate endothelial functions

E41K Mutation Activates Brutons Tyrosine Kinase by Stabilizing an Inositol Hexakisphosphate Dependent Invisible Dimer

The paper investigates the E41K mutation in BTK, showing it stabilizes an IP6-dependent PH-TH dimer, activating BTK independently of PIP3 binding.

High-resolution structures illuminate key principles underlying voltage and LRRC26 regulation of Slo1 channels

The paper determines high-resolution structures of Slo1 channels with mutations and LRRC26 subunits to elucidate voltage and auxiliary subunit regulation mechanisms.

Firefighter Helmets and Cervical Intervertebral Kinematics: An OpenSim-Based Biomechanical Study

This study uses OpenSim to analyze how different firefighter helmet designs affect cervical spine kinematics, finding that US-style helmets with superior center of mass cause more pronounced kinematic changes.

Investigating the Role of Neck Muscle Activation and Neck Damping Characteristics in Brain Injury Mechanism

This study examines how neck muscle activation and damping characteristics affect traumatic brain injury metrics in simulated impacts.

An electromyography-based multi-muscle fatigue model to investigate operational task performance

The paper develops and validates a multi-muscle fatigue model using EMG parameters and muscle ratios to predict fatigue in operational tasks.

Dissecting the properties of circulating IgG against Group A Streptococcus through a combined systems antigenomics-serology workflow

This paper develops a combined systems antigenomics-serology workflow to characterize circulating IgG against Group A Streptococcus, revealing antigen repertoire and functional properties of antibodies in healthy and infected individuals.

Telomeres control human telomerase (hTERT) expression through non-telomeric TRF2

This paper shows telomere length regulates hTERT expression by modulating TRF2 binding and PRC2-mediated repression, revealing a self-regulatory mechanism in cancer.

Architecture and rearrangements of a sperm-specific Na+/H+ exchanger

This study determines the structure of SLC9C1, a sperm-specific Na+/H+ exchanger, revealing its tripartite organization and how it integrates voltage and cyclic nucleotide signals.

The Pex6 N1 domain is required for Pex15 binding and proper assembly with Pex1

This study identifies the Pex6 N1 domain's role in binding Pex15 and stabilizing the Pex1/Pex6 heterohexamer, essential for peroxisome function.

NaV1.6 inhibition drives the efficacy of voltage-gated sodium channel inhibitors to prevent electrically induced seizures in both wild type and Scn8aN1768D/+ gain-of-function mice

The paper shows that inhibiting NaV1.6 reduces seizures in both wild-type and Scn8aN1768D/+ mice, suggesting NaV1.6 is a key target for anti-seizure drugs.

Regulation of shelterin proteins TERF2IP and TRF2 by H3K4me3-p65 axis drives hyperglycemia dependent endothelial senescence

This study shows hyperglycemia increases TERF2IP and TRF2 via H3K4me3-p65 axis, driving endothelial senescence through p53 and p21 upregulation.

Anticipatory Biogenesis of Hepatic Fed MicroRNAs is Regulated by Metabolic and Circadian Inputs

The paper shows that hepatic microRNAs increase during fasting to anticipate refeeding, regulated by metabolic and circadian factors, with potential therapeutic implications for metabolic diseases.

Phenotypic and genotypic detection of the virulence factors and their association with antibiotic resistance in Enterococcus species

Potent, Gut-Restricted Inhibitors of Divalent Metal Transporter 1 (DMT1): Preclinical Efficacy Against Iron Overload and Safety Evaluation

This paper identifies XEN602, a potent, gut-restricted DMT1 inhibitor, showing efficacy in reducing iron overload in rats and pigs with minimal systemic exposure.

Disassembly of embryonic keratin filaments promotes pancreatic cancer

This study shows that phosphorylation of K17 promotes pancreatic cancer metastasis and shorter survival by disassembling keratin filaments and enabling nuclear translocation.

Targeting keratin 17-mediated reprogramming of de novo pyrimidine biosynthesis to overcome chemoresistance in pancreatic cancer

This study identifies K17-mediated pyrimidine biosynthesis as a mechanism of chemoresistance in PDAC and shows that targeting DHODH with Brequinar enhances the efficacy of chemotherapy.

Invasive streptococcal infection can lead to the generation of cross-strain opsonic antibodies

This study examines opsonic antibody responses to invasive S. pyogenes infections, finding modest increases in antibody binding and variable opsonic capacity across strains.

Arf GTPase activates the WAVE Regulatory Complex through a novel binding site

This study identifies a novel Arf1 binding site on WRC that drives activation through a mechanism distinct from Rac1.

Structures reveal a key mechanism of WAVE Regulatory Complex activation by Rac1 GTPase

The paper reports WAVE Regulatory Complex structures bound to Rac1, revealing how Rac1 binding at the A site activates WRC to drive actin polymerization.

NBI-921352, a First-in-Class, Na V 1.6 Selective, Sodium Channel Inhibitor That Prevents Seizures in Scn8a Gain-of- Function Mice, and Wild-Type Mice and Rats

This paper describes NBI-921352, a selective NaV1.6 inhibitor that prevents seizures in Scn8a gain-of-function mice and wild-type models, with better efficacy and tolerability than existing antiseizure drugs.

Chemical exploration of a highly selective scaffold with activity against intracellular Mycobacterium tuberculosis

The paper identifies thiourea derivatives with high potency against intracellular Mycobacterium tuberculosis and good selectivity over eukaryotic cells.

Telomere length sensitive regulation of Interleukin Receptor 1 type 1 (IL1R1) by the shelterin protein TRF2 modulates immune signalling in the tumour microenvironment

The paper shows that telomere length modulates IL1R1 expression via TRF2 binding, affecting immune signaling and macrophage infiltration in TNBC.

An evolutionary divergent thermodynamic brake in ZAP-70 finetunes the kinetic proofreading in T cell

This study identifies a thermodynamic brake in ZAP-70 that regulates T cell signaling kinetics and ligand selectivity, with evolutionary implications for immune system divergence.