Substrate selectivity of the PRDM9 lysine methyltransferase domain.
J. N. Hanquier, K. Sanders, C. A. Berryhill, F. K. Sahoo, A. Hudmon, J. Z. Vilseck, E. M. Cornett
This study identifies PRDM9's substrate selectivity, showing it preferentially methylates non-histone proteins over histones, with structural and biochemical validation.
bioRxiv · Oct 12, 2022Biochemistry